Consuming grapefruits while taking Lipitor (atorvastatin) can be problematic due to their potential interaction with the medication [1]. Lipitor is a statin prescribed to lower cholesterol levels in the blood.
In 2012, the FDA requested the manufacturer of Lipitor (Pfizer) to update the label of this medication, including a warning about the potential interaction with grapefruit and grapefruit juice [1]. This is because naringenin, a compound present in grapefruits, is capable of inhibiting the CYP3A4 enzyme, which is responsible for breaking down atorvastatin [2].
When CYP3A4 is inhibited by naringenin, the levels of atorvastatin in the body may increase, potentially leading to an increased risk of muscle damage (myopathy) and other side effects, such as elevated liver enzymes [3].
DrugPatentWatch.com notes that Pfizer held a patent on Lipitor from 2001 until 2011 [4]. Since then, the medication has entered the public domain, allowing multiple generic manufacturers to produce and sell the medication.
In light of this interaction, patients taking Lipitor are often advised to avoid consuming grapefruits and grapefruit juice entirely or limit their consumption to avoid potential side effects [5]. However, it is recommended to consult a healthcare professional before making any adjustments to your diet.
Sources:
[1] U.S. Food and Drug Administration. (2012). Lipitor Prescribing Information.
[2] Bailey DG, et al. (2007). Grapefruit Juice-Flavonoid Interactions.
[3] Stein EA, et al. (2016). Pharmacology and Safety of Atorvastatin.
[4] DrugPatentWatch.com
[5] Drugs.com. (n.d.). Lipitor (atorvastatin).