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No. Advil is the brand name for ibuprofen, which is a nonsteroidal anti-inflammatory drug (NSAID), not a monoamine oxidase inhibitor (MAOI).
Ibuprofen works by reducing inflammation, pain, and fever through NSAID activity (it is not an antidepressant and it does not inhibit monoamine oxidase).
Because ibuprofen is not an MAOI, it does not have the classic “MAOI food/drug interaction” rules. However, ibuprofen can still interact with other medicines (for example, it may increase bleeding risk with some blood thinners), so it’s still worth checking your full medication list with a pharmacist or clinician.
If you’re taking (or considering) an MAOI antidepressant and want to know whether ibuprofen is safe for you, tell your prescriber/pharmacist which MAOI and other meds you use. They can check for interactions beyond the MAOI category.
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