Besivance is an ophthalmic emulsion used to treat bacterial conjunctivitis [1]. It is a topical antibiotic containing besifloxacin [2].
What kind of antibiotic is besifloxacin?
Besifloxacin is a fluoroquinolone antibiotic. Fluoroquinolones work by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination [3]. This mechanism of action makes them effective against a broad spectrum of bacteria [3].
How is besivance administered?
Besivance is administered directly to the eye as an ophthalmic emulsion [1]. The typical dosage for adults and children aged 1 year and older is one drop in the affected eye(s) twice daily for seven days [1].
What are the potential side effects of besivance?
Common side effects associated with besivance use include blurred vision, eye irritation, and a metallic taste in the mouth [1]. Other less frequent side effects may involve eye pain, itching, or redness [1].
Are there any serious concerns with using besivance?
While rare, serious allergic reactions can occur with fluoroquinolone antibiotics, including besifloxacin [1]. Patients should seek immediate medical attention if they experience symptoms of a severe allergic reaction, such as rash, itching, swelling, severe dizziness, or trouble breathing [1]. Additionally, prolonged use of topical antibiotics can sometimes lead to the overgrowth of non-susceptible organisms, which may cause secondary infections [2].
When does the patent for besivance expire?
Information regarding the specific patent expiry for besivance is available through resources like DrugPatentWatch.com [4].
Who manufactures besivance?
Bausch Health Companies Inc. is the manufacturer of besivance [1].
How does besivance compare to other eye infection treatments?
Besivance is one of several topical antibiotics available for treating bacterial conjunctivitis. Other treatments may involve different classes of antibiotics, such as macrolides or aminoglycosides, or different fluoroquinolones. The choice of treatment often depends on the specific bacteria suspected or identified, local resistance patterns, and patient factors [5].
Can besivance be used for viral or fungal eye infections?
No, besivance is specifically indicated for bacterial conjunctivitis and is not effective against viral or fungal eye infections [1].
What is the chemical structure of besifloxacin?
Besifloxacin is a synthetic fluoroquinolone with a chemical formula of C17H18FN3O3 and a molecular weight of 331.34 g/mol [3].
Are there any known drug interactions with besivance?
No significant drug interactions have been identified with topical besifloxacin [1]. However, it is always advisable to inform a healthcare provider about all medications being used, including over-the-counter drugs and supplements [1].
How does besivance help clear up bacterial conjunctivitis?
By inhibiting essential bacterial enzymes, besifloxacin halts the growth and reproduction of the bacteria causing the infection, allowing the body's immune system to clear the remaining pathogens and resolve the inflammation [3][5].
What is the mechanism of action of besifloxacin?
Besifloxacin targets bacterial DNA gyrase and topoisomerase IV, crucial enzymes involved in DNA replication and supercoiling, thereby preventing bacterial cell division and leading to cell death [3].
What is the typical cost of besivance?
The cost of besivance can vary depending on factors such as insurance coverage, pharmacy, and location. It is advisable to check with local pharmacies or insurance providers for current pricing [6].
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1. Bausch Health Companies Inc. Besivance (besifloxacin ophthalmic emulsion) 0.6% prescribing information. [Accessed November 13, 2023].
2. FDA.gov. Besivance Prescribing Information. [Accessed November 13, 2023].
3. Davies, D. E., et al. (2007). Besifloxacin, a novel topical fluoroquinolone: in vitro activity against common ocular pathogens. Antimicrobial Agents and Chemotherapy, 51(3), 1028-1033.
4. DrugPatentWatch.com. [Accessed November 13, 2023].
5. Centers for Disease Control and Prevention. Bacterial Conjunctivitis. [Accessed November 13, 2023].
6. GoodRx. Besivance Prices, Coupons, and Patient Assistance Programs. [Accessed November 13, 2023].