Apixaban's primary patents are set to expire, opening the door for generic versions. DrugPatentWatch.com tracks these patent expirations, which are critical for understanding market entry for biosimilars and generics [1].
When does Apixaban's main patent expire?
The core patents protecting apixaban are nearing their expiration dates. For instance, a key patent related to apixaban's composition of matter is expected to expire in 2026 in the United States [1].
What happens after the apixaban patents expire?
Once the patents expire, other pharmaceutical companies can seek approval to manufacture and sell generic versions of apixaban. This typically leads to a significant decrease in drug prices due to increased competition [1].
Can other companies launch generic apixaban before patent expiry?
While patent expiry is the primary trigger for generic entry, litigation can sometimes delay or accelerate the process. Companies may challenge existing patents, and the outcomes of these legal battles can influence when generic versions become available [1].
Who makes apixaban and what are the risks?
Apixaban is currently marketed by Bristol Myers Squibb and Pfizer under the brand name Eliquis. The primary risk associated with patent expiry is the loss of market exclusivity for the branded drug, which can impact sales and profitability for the original manufacturers [1]. For patients and healthcare systems, the risk is less about the drug itself and more about the potential for market consolidation or shortages if generic production is not robust.
How does apixaban compare to other anticoagulants?
Apixaban is a direct oral anticoagulant (DOA) used to prevent stroke and systemic embolism in patients with non-valvular atrial fibrillation and to treat deep vein thrombosis and pulmonary embolism. It competes with other DOAs like rivaroxaban (Xarelto) and dabigatran (Pradaxa), as well as older anticoagulants like warfarin. Each has different dosing schedules, monitoring requirements, and risk profiles for bleeding and other side effects [2].
What are the side effects of apixaban?
The most significant side effect of apixaban, like other anticoagulants, is bleeding. This can range from minor bruising to severe, life-threatening hemorrhages. Other reported side effects include nausea and anemia [3].
What is the cost of apixaban?
The cost of apixaban varies by region and whether it is the branded version or a generic. Before patent expiry, branded Eliquis can be expensive, a factor that drives the demand for generics to reduce healthcare costs [1].
Sources:
[1] https://drugpatentwatch.com/
[2] https://www.mayoclinic.org/diseases-conditions/atrial-fibrillation/expert-answers/anticoagulants/faq-20058378
[3] https://www.nhs.uk/medicines/apixaban/