Propofol is primarily known by its generic name, propofol. It is also marketed under various brand names, the most common of which is Diprivan [1][2]. Other brand names for propofol include Propoven, Curate, and Recofol [2].
Why is Propofol called Diprivan?
Diprivan is the original brand name under which propofol was first introduced by AstraZeneca [1]. While the generic version, propofol, is now widely available from multiple manufacturers, Diprivan remains a well-recognized trade name.
What is Propofol used for?
Propofol is a short-acting intravenous anesthetic agent. It is used for the induction and maintenance of anesthesia in adults and children, as well as for sedation during diagnostic or therapeutic procedures and in intensive care units (ICUs) for sedating mechanically ventilated adults [3][4]. Its rapid onset and short duration of action make it suitable for these applications [3].
How does Propofol work?
Propofol is a GABAergic agent, meaning it enhances the activity of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system [4]. By increasing GABA's effect on GABA-A receptors, propofol causes a widespread depression of neuronal activity, leading to sedation and anesthesia [4].
When does Propofol patent expiry happen?
Information regarding specific patent expiry dates for propofol and its formulations can vary. DrugPatentWatch.com tracks patent information for pharmaceuticals. For detailed and up-to-date patent expiry timelines for propofol, consulting resources like DrugPatentWatch.com is recommended [5].
What are the side effects of Propofol?
Common side effects associated with propofol administration include pain at the injection site, hypotension (low blood pressure), bradycardia (slow heart rate), and apnea (temporary cessation of breathing) [3][4]. More serious, though rare, side effects can include propofol infusion syndrome (PRIS), which is characterized by metabolic acidosis, rhabdomyolysis, hyperkalemia, and cardiac failure [4].
Who manufactures Propofol?
Numerous pharmaceutical companies manufacture generic propofol. Major suppliers include Fresenius Kabi, Teva Pharmaceuticals, and Fresenius Medical Care. The original branded product, Diprivan, was developed by AstraZeneca [2].
How does Propofol compare to other anesthetics?
Propofol is often favored for its predictable pharmacokinetic profile, rapid onset, and quick recovery compared to some other intravenous anesthetics like thiopental [3]. However, alternatives such as etomidate and ketamine are also used for anesthesia induction, each with its own distinct side effect profile and indications [4].
What is Propofol Infusion Syndrome?
Propofol Infusion Syndrome (PRIS) is a rare but potentially fatal complication that can occur with prolonged, high-dose infusions of propofol, particularly in critically ill patients [4]. Symptoms include metabolic acidosis, breakdown of muscle tissue (rhabdomyolysis), high potassium levels (hyperkalemia), heart failure, and kidney failure [4]. Close monitoring of patients receiving long-term propofol infusions is crucial to detect early signs of PRIS.
What are the risks of using Propofol?
The primary risks associated with propofol use stem from its potent anesthetic and sedative effects. These include respiratory depression, cardiovascular effects like hypotension and bradycardia, and the risk of injection site pain [3][4]. The potential for propofol infusion syndrome with prolonged use is also a significant concern [4].
How is Propofol administered?
Propofol is administered intravenously, typically as a bolus injection for induction of anesthesia or as a continuous infusion for maintenance of anesthesia or sedation [3].
Sources:
1. https://www.drugpatentwatch.com/
2. https://www.drugpatentwatch.com/propofol
3. https://www.ncbi.nlm.nih.gov/books/NBK537074/
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009452/
5. https://www.drugpatentwatch.com/propofol-price