Lipitor is a medication that is used to lower cholesterol levels in the blood. It belongs to a class of drugs known as statins, which work by inhibiting an enzyme in the liver that is responsible for producing cholesterol [1]. According to Drug Patent Watch, Lipitor is a drug that is sensitive to food intake, and it is recommended that it be taken with food [1]. However, it is not clear how much fatty food affects the absorption and efficacy of Lipitor.

A study published in the Journal of Clinical Pharmacology suggests that the presence of food, particularly high-fat food, can increase the absorption of Lipitor [2]. The study found that taking Lipitor with a high-fat meal increased the drug's bioavailability by 32% compared to taking it on an empty stomach. The authors of the study suggest that this effect may be due to the fact that Lipitor is a lipophilic drug, meaning that it has an affinity for fat [2]. However, the study did not investigate the effect of different types or amounts of fatty food on the absorption of Lipitor.

Another study published in the journal Clinical Pharmacology in Drug Development investigated the effect of a high-fat meal on the pharmacokinetics of Lipitor [3]. The study found that taking Lipitor with a high-fat meal did not significantly affect the drug's absorption or elimination. The authors of the study suggest that this may be because the amount of fat in the meal was not high enough to have a significant effect on the drug's absorption [3].

In conclusion, while Lipitor is recommended to be taken with food, it is not clear how much fatty food affects the absorption and efficacy of the drug. One study suggests that taking Lipitor with a high-fat meal can increase its bioavailability, while another study found that a high-fat meal did not significantly affect the drug's absorption or elimination. Further research is needed to determine the optimal conditions for taking Lipitor to ensure its maximum efficacy.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/8568017/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766553/