Cosentyx and Vaccination Basics
Cosentyx (secukinumab), an IL-17 inhibitor for psoriasis, psoriatic arthritis, and ankylosing spondylitis, suppresses parts of the immune system. This raises infection risks, so vaccination timing matters. Guidelines prioritize live vaccines before starting Cosentyx and inactivated vaccines during treatment.[1]
Live Vaccines Before Starting Cosentyx
Avoid live vaccines (e.g., MMR, varicella, oral polio, yellow fever, nasal flu) while on Cosentyx and for up to 4-6 weeks after stopping it, due to dissemination risk in immunocompromised patients. Get them at least 4 weeks before your first dose.[1][2]
Inactivated and Recombinant Vaccines During Treatment
These are safe and recommended anytime, including during Cosentyx therapy:
- Annual inactivated influenza vaccine.
- COVID-19 vaccines (mRNA or protein-based).
- Tdap (tetanus, diphtheria, pertussis).
- Pneumococcal (PCV13, PPSV23).
- Shingles (Shingrix, recombinant—preferred over live Zostavax).
- HPV, hepatitis A/B, meningococcal.[1][3]
| Vaccine Type | Timing Relative to Cosentyx |
|--------------|-----------------------------|
| Live | ≥4 weeks before start; avoid during/after |
| Inactivated | Anytime, including mid-treatment |
Standard Adult Schedule Adjustments
Follow CDC adult immunization schedule, but screen for prior immunity first (e.g., varicella titers). Key updates post-Cosentyx start:
- Flu: Yearly in fall.
- COVID-19: Per current CDC boosters.
- Pneumococcal: One-time PCV15/20 + PPSV23 if ≥65 or high-risk.
- Shingrix: Two doses, 2-6 months apart—start anytime.[3][4]
Post-Cosentyx Discontinuation Schedule
If stopping Cosentyx (e.g., remission or switch), wait 4-6 weeks for live vaccines. Restart inactivated vaccines immediately if due. No universal "catch-up" delay beyond that; consult your doctor for serology checks.[1][2]
Patient Concerns and Exceptions
Immunosuppression varies—rheumatologists may delay non-urgent vaccines during flares. Kids on Cosentyx follow pediatric schedules with same live vaccine rules. Report infections post-vaccination.[2]
[1]: Cosentyx Prescribing Information (Novartis)
[2]: ACR Guidelines on Vaccinations in Rheumatic Diseases
[3]: CDC Adult Immunization Schedule
[4]: Shingrix Prescribing Information (GSK)