Below is a very general, ball‑park estimate of what you might expect to pay out‑of‑pocket for each of the three drugs you mentioned. The numbers are based on current U.S. retail prices and the typical copay/coinsurance patterns you’ll see with most commercial insurance plans and Medicare Part D. Actual costs can be higher or lower depending on:
- Your insurance formulary (generic vs. brand‑name tier, specialty pharmacy rules, prior‑authorization requirements)
- The specific dosage and pill strength you’re prescribed
- Whether you’re on a high‑deductible plan
- Any cost‑sharing savings programs offered by the manufacturer or your pharmacy benefit manager
1. Orzeyful (brand‑name mirtazapine)
| Scenario | Typical out‑of‑pocket cost per month | Notes |
|----------|-------------------------------------|-------|
| Brand‑name (Orzeyful) – 15 mg/tablet | $200–$300 | Most insurers place this in a “specialty” or “brand‑tier” category, so you may face a 20–40 % coinsurance or a $25–$50 copay. |
| Generic mirtazapine – 15 mg/tablet | $30–$80 | If your formulary has a generic tier, copays can be $5–$15, with most of the cost paid by the insurer. |
| Generic mirtazapine – 15 mg/tablet (high‑deductible) | $80–$150 | You may need to cover the full price until you meet your deductible. |
2. Sunosi (solriamfetol)
| Scenario | Typical out‑of‑pocket cost per month | Notes |
|----------|-------------------------------------|-------|
| Brand‑name – 150 mg/tablet | $250–$350 | Often placed in a “brand‑tier” with a 25–35 % coinsurance. |
| Generic solriamfetol – not yet available | — | No generic yet, so all brand‑tier pricing applies. |
3. Wakix (modafinil)
| Scenario | Typical out‑of‑pocket cost per month | Notes |
|----------|-------------------------------------|-------|
| Brand‑name – 100 mg/tablet | $250–$350 | Usually a brand‑tier drug; copays can be $20–$50 or coinsurance 20–35 %. |
| Generic modafinil – 100 mg/tablet | $30–$80 | Copays are usually $5–$15 if your plan has a generic tier. |
| Generic modafinil – 100 mg/tablet (high‑deductible) | $80–$150 | You might pay more until your deductible is met. |
Quick comparison (average monthly out‑of‑pocket)
| Drug |
Brand tier (typical) |
Generic tier (typical) |
| Orzeyful |
$200–$300 |
$30–$80 |
| Sunosi |
$250–$350 |
— (generic not available) |
| Wakix |
$250–$350 |
$30–$80 |
Bottom line:
If you have a plan that covers generics, you’ll pay far less for Orzeyful and Wakix, while Sunosi will still cost close to its brand‑name price because a generic isn’t available yet.
How to narrow the estimate for you
- Check your pharmacy benefit manager (PBM) – look up the drug on their website (e.g., OptumRx, Express Scripts). They’ll show you the exact copay/coinsurance for your specific pharmacy network.
- Ask your prescriber – many physicians now provide a “cost estimate” sheet with the prescription.
- Use online cost calculators – sites like GoodRx, Blink Health, or the manufacturer’s savings programs let you enter your ZIP code and see the cost at your local pharmacy.
- Ask your insurer – call the member services number or visit the insurer’s portal. They can confirm whether you’re in the correct formulary tier and whether prior authorization or step‑therapy is required.
Final caveat
These numbers are rough averages. Your actual out‑of‑pocket cost can vary based on the factors above, changes in drug pricing, and any special discount programs you qualify for. Always confirm the exact amount with your insurer or pharmacy before filling the prescription.