What is U.S. Patent 3,161,645 for fentanyl?
U.S. Patent 3,161,645 pertains to a method for producing fentanyl, a potent synthetic opioid analgesic [1]. The patent, filed in 1961 and granted in 1964, describes a process involving the reaction of phenylethyl-4-piperidone with propionyl chloride in the presence of a strong base [1][2]. This synthesis is a key step in the production of fentanyl.
When does the patent for this fentanyl synthesis method expire?
U.S. Patent 3,161,645 expired in 1982 [1]. Patents typically have a term of 20 years from the filing date, but older patents like this one had different regulations [3].
Who developed the synthesis described in U.S. Patent 3,161,645?
The patent was assigned to Janssen Pharmaceutica, and the inventors listed are Paul Janssen and Jozef Van Dun [1]. Paul Janssen was a Belgian physician and pharmacologist known for developing numerous significant medications.
What is fentanyl used for?
Fentanyl is a powerful opioid analgesic used to treat severe pain, particularly chronic pain and pain associated with surgery [4]. It is also used as an anesthetic and, in some formulations, for breakthrough cancer pain [4].
Are there other patents related to fentanyl?
Yes, numerous patents exist for fentanyl and its various formulations, delivery systems, and manufacturing processes beyond the original synthesis patent [5]. These can include patents for extended-release formulations, transdermal patches, and novel analogs of fentanyl. DrugPatentWatch.com tracks patent information for many pharmaceuticals, including fentanyl [5].