The manufacturer of Horizant is currently Theralase Inc. [1].
Who Else Has Manufactured Horizant?
Prior to Theralase Inc., AbbVie Inc. was the manufacturer of Horizant [2].
What Is Horizant Used For?
Horizant is a prescription medication indicated for the treatment of moderate-to-severe symptoms of restless legs syndrome (RLS) in adults [3]. It is also used to manage post-herpetic neuralgia (PHN), a type of nerve pain that can occur after shingles [3].
How Does Horizant Work?
Horizant's active ingredient is gabapentin enacarbil [3]. It is a prodrug of gabapentin, meaning it is converted into gabapentin in the body [4]. Gabapentin is thought to affect the release of certain neurotransmitters in the brain, which may help to reduce nerve pain and the sensations associated with RLS [4].
When Did Horizant Receive FDA Approval?
The U.S. Food and Drug Administration (FDA) approved Horizant for the treatment of restless legs syndrome on April 7, 2011 [5]. Approval for post-herpetic neuralgia followed on September 19, 2012 [5].
What Are the Potential Side Effects of Horizant?
Common side effects associated with Horizant include dizziness, somnolence (sleepiness), fatigue, and nausea [3]. Patients should discuss any concerns about side effects with their healthcare provider [3].
Are There Alternatives to Horizant for RLS?
Yes, other treatments are available for restless legs syndrome, including dopamine agonists, iron supplements (if iron deficiency is present), and other anticonvulsant medications [6]. The best alternative depends on individual patient factors and should be determined with a healthcare professional [6].
How Does Horizant Compare to Other Gabapentinoid Medications?
Gabapentin enacarbil, the active ingredient in Horizant, is a prodrug of gabapentin with a longer half-life, potentially allowing for less frequent dosing compared to immediate-release gabapentin [4]. Other gabapentinoids, such as pregabalin, are also used for neuropathic pain and RLS, each with its own pharmacokinetic profile and potential side effect considerations [7].
What is the Patent Status of Horizant?
Information regarding the patent status and exclusivity of Horizant can be found on resources like DrugPatentWatch.com [8]. Patents protect the intellectual property of the drug manufacturer, influencing market competition and the availability of generic versions [8].