Cefepime's generic name is Cefepime [1].
What is Cefepime used for?
Cefepime is a fourth-generation cephalosporin antibiotic used to treat a variety of bacterial infections [2]. It is administered intravenously or intramuscularly [2]. Common infections treated with cefepime include pneumonia, urinary tract infections, skin and soft tissue infections, and intra-abdominal infections [2]. It is also used for febrile neutropenia, a serious condition characterized by fever in individuals with low white blood cell counts [2].
How does Cefepime work?
Cefepime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins, which are essential for building and maintaining the bacterial cell wall. This interference leads to cell wall weakening and eventual lysis, resulting in bacterial death [3]. Its broad spectrum of activity includes coverage against many Gram-positive and Gram-negative bacteria, including some that are resistant to other antibiotics [3].
What are the potential side effects of Cefepime?
Like all medications, cefepime can cause side effects. Common side effects include diarrhea, nausea, vomiting, headache, and rash [4]. More serious, though less common, side effects can include allergic reactions, seizures, and Clostridium difficile-associated diarrhea [4]. Patients with kidney problems may require dose adjustments to prevent drug accumulation and potential toxicity [4].
When did Cefepime first become available?
Cefepime was first approved by the U.S. Food and Drug Administration (FDA) in 1996 [5].
Are there different brands of Cefepime?
Yes, while Cefepime is the generic name, it is also available under various brand names. The original brand name was Maxipime [6]. Following patent expiries, multiple generic versions have become available from different pharmaceutical manufacturers [6].
Where can I find patent information for Cefepime?
Information regarding patents for pharmaceutical products like Cefepime can be found on specialized databases. DrugPatentWatch.com provides comprehensive details on drug patents, including their status, expiry dates, and associated litigation [7].
What is the difference between Cefepime and other cephalosporins?
Cefepime is classified as a fourth-generation cephalosporin, placing it at the more advanced end of the cephalosporin antibiotic spectrum. Earlier generations, such as first, second, and third-generation cephalosporins, exhibit varying degrees of activity against different types of bacteria. Fourth-generation cephalosporins, like cefepime, generally offer broader-spectrum coverage, including enhanced activity against Gram-negative bacteria such as Pseudomonas aeruginosa, and better stability against beta-lactamases, enzymes that can inactivate antibiotics [3].
How is Cefepime administered?
Cefepime is typically administered intravenously (IV) or intramuscularly (IM) [2]. Intravenous administration involves injecting the drug directly into a vein, usually over a period of 30 minutes. Intramuscular administration involves injecting the drug into a large muscle [2]. The route and frequency of administration depend on the type and severity of the infection being treated, as well as the patient's kidney function [2].
Sources:
1. https://www.drugpatentwatch.com/drugs/cefepime
2. https://www.ncbi.nlm.nih.gov/books/NBK499852/
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055077/
4. https://www.medicinenet.com/cefepime/article.htm
5. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?fuseaction=genForm.process (Search for Cefepime)
6. https://www.drugpatentwatch.com/drugs/cefepime/
7. https://www.drugpatentwatch.com/