Hydroxyzine Hydrochloride 25 mg Tablet
| Item | Details |
|------|---------|
| Drug class | First‑generation antihistamine (H1 blocker) with anxiolytic, antihistaminic, anti‑emetic, and sedative properties. |
| Common uses | • Acute itching or urticaria (hives).
• Allergic reactions (skin rash, angioedema).
• Anxiety or pre‑operative sedation.
• Nausea/vomiting (short‑term).
• As part of a “pre‑med” regimen before anesthesia or surgery. |
| Typical adult dose | • 25 mg every 4–6 h as needed (max 200 mg/day).
• For anxiety or pre‑operative sedation: 25 mg 1 h before surgery.
• For allergic reactions: 25–50 mg every 4 h, not exceeding 200 mg/day. |
| Children | Generally 1–2 mg/kg (max 25 mg) every 4–6 h; dose titrated based on response and tolerability. |
| Administration | Oral, with or without food. Swallow whole; do not crush or chew. |
| Key side effects | • Drowsiness, dry mouth, blurred vision, constipation.
• At higher doses: muscle weakness, confusion, urinary retention, tachycardia.
• Rarely, paradoxical excitement, agitation, or hypersensitivity rash. |
| Contraindications | • Known hypersensitivity to hydroxyzine or any excipient.
• Severe hepatic or renal impairment (dose adjustment needed).
• Narrow‑angle glaucoma, myasthenia gravis, or severe cardiac conduction disorders. |
| Drug interactions | • CNS depressants (alcohol, benzodiazepines, opioids, barbiturates) → additive sedation.
• MAO‑inhibitors: risk of serotonin syndrome and increased sedation.
• Other antihistamines: additive anticholinergic effects.
• Antipsychotics, anticholinergics, and medications that prolong QT interval may increase cardiac risk. |
| Precautions | • Use cautiously in elderly; they’re more prone to sedation, orthostatic hypotension, and falls.
• Avoid driving or operating heavy machinery until you know how the drug affects you.
• Monitor blood pressure in patients with hypertension.
• Be vigilant for signs of hypersensitivity (rash, swelling, difficulty breathing). |
| Pregnancy / Lactation | • Category C: animal studies show fetal toxicity, but no well‑studied human data. Use only if benefits outweigh risks.
• Excreted in breast milk; lactating mothers should discuss risks with a clinician. |
| Storage | Keep at room temperature (20–25 °C) away from moisture and direct sunlight. Do not freeze. |
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Quick‑Reference Summary
- What it’s for: itching, allergies, anxiety, and as a pre‑operative sedative.
- Typical dose: 25 mg orally every 4–6 h; max 200 mg/day.
- Biggest warning: can make you very sleepy and can interact with other CNS depressants.
- If you see: severe itching, rash, swelling, chest pain, or sudden dizziness → seek medical help.
Always follow your prescribing clinician’s instructions and discuss any concerns or questions with them.