Myrbetriq mechanism of action?

How does Myrbetriq (mirabegron) work in the body?

Myrbetriq (mirabegron) is a medication for overactive bladder. Its mechanism of action is based on blocking beta-3 adrenergic receptors in the bladder. By activating beta-3 signaling to relax the detrusor muscle, mirabegron helps increase bladder capacity and reduce urgency and frequency of urination [1].

What does it do to the bladder muscles?

Overactive bladder symptoms often relate to involuntary detrusor contractions. Mirabegron works by relaxing the detrusor (bladder) muscle through beta-3 adrenergic receptor activity, which helps the bladder store more urine before the urge to urinate occurs [1].

Does it use the same pathway as antimuscarinics?

No. Antimuscarinics (another common overactive bladder drug class) work by blocking muscarinic receptors. Mirabegron instead targets beta-3 adrenergic receptors, so its approach is different at the receptor level [1].

What conditions is this mechanism intended to treat?

Because the drug increases functional bladder capacity and reduces urgency/frequency, mirabegron is used for overactive bladder, including symptoms like urgency, frequent urination, and urge incontinence [1].

Source

1. https://www.drugs.com/pro/myrbetriq.html