Aspirin is a commonly used medication for pain relief and anti-inflammatory purposes. It is essential to understand how food affects aspirin absorption to ensure its optimal efficacy.

According to Drug Patent Watch [1], aspirin is absorbed in the stomach and small intestine. Food intake can affect aspirin absorption by changing the pH level of the stomach, which can affect the solubility of aspirin. For instance, taking aspirin with food can delay its absorption, while taking it on an empty stomach can increase its absorption rate.

A recent study published in the Journal of Thrombosis and Thrombolysis [2] found that the type of food consumed can also affect aspirin absorption. The study showed that a high-fat meal decreased aspirin absorption by 50% compared to a low-fat meal. The researchers suggested that the fat content in the meal could have reduced the solubility of aspirin, leading to decreased absorption.

Another study published in the Journal of Clinical Pharmacology [3] found that the timing of food intake could also affect aspirin absorption. The study showed that taking aspirin with a meal resulted in a slower and more prolonged absorption compared to taking it 2 hours after a meal.

In conclusion, food intake can significantly affect aspirin absorption. The type of food, the timing of food intake, and the pH level of the stomach can all impact the solubility and absorption of aspirin. Patients should be advised to take aspirin as directed by their healthcare provider and to consult with them regarding the best way to take aspirin with or without food.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ASPIRIN
[2] https://link.springer.com/article/10.1007/s11239-020-02051-5
[3] https://pubmed.ncbi.nlm.nih.gov/3802700/