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What side effects do patients most worry about with high-dose Ativan? High doses of Ativan (lorazepam) can slow breathing and lower blood pressure enough to cause serious harm. Respiratory depression is the chief concern, especially when taken with opioids or alcohol. How does Ativan affect the heart and blood pressure? Ativan works on the GABA system in the brain. When the dose climbs, it can drop blood pressure and heart rate. Patients with existing heart problems may experience dizziness or fainting. Can high-dose Ativan lead to seizures? Paradoxically, stopping high-dose Ativan suddenly can trigger withdrawal seizures. Doctors usually taper the drug over weeks rather than stop es
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