Vaccines to Avoid with Cosentyx
Cosentyx (secukinumab), an IL-17A inhibitor for psoriasis, psoriatic arthritis, and ankylosing spondylitis, suppresses the immune system. Live vaccines can cause infection in immunocompromised patients, so avoid them during treatment.[1]
- Live vaccines contraindicated: BCG, cholera, dengue, influenza (live intranasal), measles/mumps/rubella (MMR), oral polio, rotavirus, smallpox, typhoid (oral), varicella (chickenpox), yellow fever, and zoster (shingles).[1][2]
Why Live Vaccines Are Risky
These vaccines use weakened live viruses or bacteria that replicate in the body to build immunity. With Cosentyx impairing immune response, they may lead to disseminated infection. Inactivated or subunit vaccines (e.g., flu shot, Tdap, HPV, pneumococcal) are safe and recommended before starting treatment.[1][3]
Timing for Vaccinations
- Complete all live vaccines at least 4 weeks before first Cosentyx dose.
- No live vaccines during treatment or for several months after stopping (risk unclear; consult doctor).
- Update non-live vaccines per schedule; they don't interact.[1][2]
What If You've Had Recent Vaccines?
If a live vaccine was given within 4 weeks before Cosentyx, delay treatment until immune response develops (typically 4 weeks post-vaccination). Post-treatment, wait until immune function recovers—often 3+ months, but individualized.[1]
Common Patient Questions on Vaccines and Cosentyx