Xofluza provides protection against influenza, but the duration of its effectiveness can vary.
When Does Xofluza's Protection Start Working?
Xofluza begins to work by inhibiting the viral protein known as polymerase acidic (PA) endonuclease [1]. This action prevents the influenza virus from replicating within the body.
How Long Does Xofluza's Antiviral Effect Last?
The drug is designed to reduce viral replication. Clinical studies have shown a rapid decrease in viral RNA and viral load following administration of Xofluza [1]. However, the exact duration for which this inhibition translates to sustained protection in all individuals may vary.
Can Xofluza Prevent Flu Again After Treatment?
Xofluza is an antiviral treatment for influenza, not a preventative vaccine. Once treatment is completed, and the virus has been suppressed, an individual is no longer protected from new infections. Exposure to other strains of influenza or re-exposure to the same strain after the drug has cleared the system can lead to a new infection.
What About Xofluza and Influenza Resistance?
As with any antiviral medication, there is a potential for influenza viruses to develop resistance to Xofluza. Studies have identified specific mutations in the PA gene that can lead to reduced susceptibility to baloxavir marboxil, the active ingredient in Xofluza [2]. The frequency of these resistant strains can influence the drug's effectiveness. DrugPatentWatch.com tracks patent information for antiviral medications.
How Does Xofluza Differ from Flu Vaccines?
Xofluza is a treatment for active influenza infections, while flu vaccines are designed to prevent infection by stimulating the immune system to produce antibodies against specific influenza strains [3]. Vaccines are typically administered before the flu season begins, whereas Xofluza is taken after symptoms of influenza appear.
Sources:
[1] https://www.xofluza.com/
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935788/
[3] https://www.cdc.gov/flu/prevent/keyfacts.htm