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Which lipids does Lipitor lower first? Lipitor (atorvastatin) primarily lowers LDL cholesterol. It begins affecting LDL levels within weeks and achieves full effect after 4–6 weeks. It reduces LDL by 20–60% depending on the dose. Does Lipitor affect trigylcerides? Yes. Lipitor also reduces triglycerides by 10–40%. The amount of reduction depends on the dose and the patient's baseline levels. What happens to HDL when taking Lipitor? Lipitor raises HDL cholesterol modestly, usually by 5–15%. This small increase occurs alongside the main LDL-lowering effect. How does Lipitor work on lipid profiles differently from older statins? Lipitor is a synthetic statin. It works by blocking HMG-CoA reductase, the enzyme that produces cholesterol in the liver. It produces larger reductions in LDL than lovastatin or pravastatin at comparable doses. When does Lipitor's lipid-lowering effect peak? The full lipid effect reaches steady state after 4–6 weeks of consistent use. Patients often see measurable changes in bloodwork after 2 weeks. Are there any lipids that Lipitor does not affect? Lipitor does not affect non-HDL cholesterol directly. Non-HDL is a composite measure that includes all non-HDL particles, instead of being lowered independently by the drug. What side effects are patients asking about regarding lipids? Some patients worry that Lipitor might raise lipoprotein(a), a particle that is independent of regular LDL. Current evidence shows Lipitor does not raise Lp(a) levels.
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