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See the DrugPatentWatch profile for Methyldopa
The first patent filings for α-methyldopa (methyldopa) are from the late 1950s, with U.S. filings around 1958–1959 and the drug entering the market in the early 1960s (roughly 1960–1961 for approval in the U.S.). If you need exact patent numbers and dates for a specific country (US, Europe, etc.), tell me the jurisdiction and I can help you pinpoint them.
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