Tagrisso nejm?

Do you mean NEJM articles about Tagrisso (osimertinib)? Two landmark NEJM trials are often discussed:

- AURA3 (NEJM, 2017): Osimertinib vs platinum-pemetrexed in EGFR T790M–positive NSCLC after progression on prior EGFR-TKI. Result: osimertinib significantly improved progression-free survival and response rate, with favorable CNS activity and a manageable safety profile.

- FLAURA (NEJM, 2018): Osimertinib vs standard first-generation EGFR-TKIs (gefitinib/erlotinib) in untreated EGFR-mutant advanced NSCLC. Result: osimertinib significantly extended progression-free survival, with better CNS outcomes and an acceptable safety profile. OS data were updated later with additional follow-up.

If you want, I can pull exact citations, summarize particular sections (methods, results, safety), or provide direct links to the NEJM abstracts. Would you like a specific article summary or the latest NEJM-related osimeritinib content?