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Is mirtazapine an antihistamine?

See the DrugPatentWatch profile for mirtazapine

Not exactly. Mirtazapine isn’t classified as an antihistamine. It’s an antidepressant (a noradrenergic and specific serotonergic antidepressant, or NaSSA). However, it does block histamine H1 receptors quite strongly, which gives sedating effects and can contribute to weight gain.

Key points:
- Class: NaSSA antidepressant
- Receptor actions (relevant to effects): blocks α2-adrenergic receptors; blocks 5-HT2 and 5-HT3 receptors; strong H1 (histamine) receptor antagonism
- Effects: sedation/drowsiness, increased appetite/weight gain, improved mood for many patients
- Common side effects: sleepiness, weight gain, dizziness, dry mouth, constipation

If you’re considering this medication or have concerns about side effects or interactions, talk with a healthcare professional for personalized guidance.



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