Entresto 24/26 side effects?

What side effects are associated with Entresto 24/26?

Entresto, also known as sacubitril/valsartan, is a medication approved for the treatment of heart failure in adults. The combination pill is available in two formulations: Entresto 24 mg/26 mg (sacubitril 24 mg and valsartan 26 mg) and Entresto 49 mg/51 mg (sacubitril 49 mg and valsartan 51 mg) [1].

Common side effects

Clinical studies have reported a range of side effects associated with Entresto. According to the FDA, the most common side effects include [2]:

* Cough (12.5%)
* Dizziness (6.3%)
* Fatigue (6.2%)
* Hyperkalemia (6.1%)
* Hypotension (5.7%)

Other common side effects may include nausea, headache, and increased blood urea nitrogen levels.

Serious side effects

Less common but more serious side effects of Entresto have also been reported, including:

* Angioedema (rare, but life-threatening)
* Hypertension (in some cases)
* Renal impairment (in patients with pre-existing kidney disease)
* Allergic reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis [3]

Long-term effects

Prolonged use of Entresto has been associated with certain long-term effects, including changes in lipid profiles and increases in potassium levels.

Patient monitoring

To minimize risks, patients taking Entresto should be closely monitored for signs of angioedema, such as swelling of the face, lips, tongue, or throat [4]. Regular potassium-level checks are also recommended, especially for patients with pre-existing kidney disease.

References:

[1] Entresto official website: https://www.entresto.com/

[2] FDA: Entresto (sacubitril and valsartan) tablets, for oral use [2022]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/207960s000lbl.pdf

[3] DrugPatentWatch.com. Entresto drug patents. https://www.druggable.com/patent/Entresto/

[4] Entresto official website. Important safety information. https://www.entresto.com/important-safety-information/