Cefuroxime axetil is an ester prodrug of cefuroxime, a second-generation cephalosporin antibiotic. It is formulated as a tablet or oral suspension [1]. The active ingredient is cefuroxime axetil, and common inactive ingredients in tablet formulations include microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, povidone, and magnesium stearate [2]. The film coating typically contains hypromellose, titanium dioxide, macrogol, and purified water [2]. For oral suspensions, inactive ingredients may include sucrose, xanthan gum, and flavorings [3].
What is cefuroxime axetil used for?
Cefuroxime axetil is prescribed to treat a range of bacterial infections. These include acute infections of the upper and lower respiratory tract, such as sinusitis, pharyngitis, tonsillitis, and acute bronchitis. It is also used for acute uncomplicated gonorrhea, and for uncomplicated urinary tract infections. Additionally, it can treat skin and soft tissue infections like cellulitis, impetigo, and infected wounds [4].
How does cefuroxime axetil work?
Cefuroxime axetil is a prodrug, meaning it is inactive until it is absorbed and metabolized in the body. Once absorbed, esterases cleave the axetil ester, releasing the active cefuroxime. Cefuroxime is a bactericidal antibiotic that works by inhibiting the synthesis of peptidoglycan, a crucial component of bacterial cell walls. This disruption leads to cell lysis and bacterial death [1][4].
What are the common side effects of cefuroxime axetil?
Common side effects associated with cefuroxime axetil include nausea, vomiting, diarrhea, and abdominal pain. Some individuals may experience headache, dizziness, or a rash. Candidiasis, an overgrowth of yeast, can also occur in the mouth or vagina [5].
When will cefuroxime axetil patents expire?
Patent expiration dates for cefuroxime axetil vary depending on the specific patent and region. Information on patent statuses and anticipated generic entry dates can be found on resources like DrugPatentWatch.com [6].
Are there alternative antibiotics to cefuroxime axetil?
Yes, other antibiotics can be used to treat bacterial infections, depending on the type of infection, the specific bacteria involved, and patient factors. Alternatives may include other cephalosporins, macrolides, or penicillins, among others [7].
Who manufactures cefuroxime axetil?
Cefuroxime axetil is manufactured by various pharmaceutical companies under different brand names, such as Ceftin and Zinacef (though Zinacef is typically the injectable form). Generic versions are also available from multiple manufacturers [8].
Sources:
[1] https://www.drugpatentwatch.com/
[2] https://www.medicines.org.uk/emc/product/4929/smpc
[3] https://www.drugs.com/ingredient/cefuroxime-axetil
[4] https://www.nhs.uk/medicines/cefuroxime/
[5] https://www.mayoclinic.org/drugs-supplements/cefuroxime-oral-route-parenteral-route/side-effects/drg-20066400
[6] https://www.drugpatentwatch.com/
[7] https://www.ncbi.nlm.nih.gov/books/NBK535397/
[8] https://www.goodrx.com/cefuroxime-axetil