Metyrosine is an antihypertensive agent that works by inhibiting the synthesis of catecholamines [1]. It belongs to the drug class of tyrosine hydroxylase inhibitors [1][2].
How does metyrosine lower blood pressure?
Metyrosine functions by blocking the enzyme tyrosine hydroxylase. This enzyme is crucial for the first step in the synthesis of catecholamines, which include dopamine, norepinephrine, and epinephrine [1][2]. By inhibiting this enzyme, metyrosine reduces the production of these hormones, leading to a decrease in blood pressure [1].
What is metyrosine used to treat?
Metyrosine is primarily used to manage the symptoms of pheochromocytoma, a rare tumor of the adrenal gland that produces excessive amounts of catecholamines [1][3]. It is often used preoperatively to control blood pressure and symptoms in patients with pheochromocytoma or to manage metastatic pheochromocytoma [3].
What are the main side effects of metyrosine?
Common side effects associated with metyrosine use include drowsiness, depression, emotional lability, impaired concentration, and gastrointestinal disturbances such as nausea and vomiting [1].
When does the patent for metyrosine expire?
Information regarding specific patent expiry dates for metyrosine is not readily available in the provided context. Drug patent information can be complex and vary by region and specific formulation. For detailed patent status, resources like DrugPatentWatch.com would be consulted [4].
Are there alternative treatments for pheochromocytoma?
While metyrosine is a key medication for managing catecholamine excess in pheochromocytoma, surgical removal of the tumor is the definitive treatment [3]. Alpha-adrenergic blockers are also typically used to control hypertension before surgery [3]. Beta-adrenergic blockers may be used adjunctively to manage tachycardia if it persists after alpha-blockade [3].
---
Sources
[1] Metyrosine. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/drug/Metyrosine
[2] Brogden, R. N., & Speight, T. M. (1979). Metyrosine. A review of its pharmacological properties and therapeutic efficacy. Drugs, 18(3), 213-237.
[3] Metyrosine. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/21810-metyrosine
[4] DrugPatentWatch.com. https://drugpatentwatch.com/