Diclofenac – EC (European Community) number
- EC number: 500‑01‑2
This is the unique identifier used by the European Medicines Agency (EMA) for the drug diclofenac (the salt form, diclofenac sodium, carries the same EC number).
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Quick reference on diclofenac sodium
| Feature | Details |
|---------|---------|
| Drug class | Non‑steroidal anti‑inflammatory drug (NSAID) |
| Common brand names | Voltaren®, Cataflam®, Flexofen®, Lodox®, etc. |
| Typical adult dose | 50 mg–100 mg PO twice daily (max 150 mg/day); topical formulations have their own dosing instructions. |
| Primary uses | Mild‑to‑moderate pain, osteoarthritis, rheumatoid arthritis, gout attacks, postoperative pain. |
| Key side‑effects | GI upset/bleeding, increased cardiovascular risk, renal impairment, hypersensitivity, hepatotoxicity. |
| Contraindications | Active GI ulceration, severe renal or hepatic disease, uncontrolled hypertension, heart failure. |
| Drug interactions | NSAIDs + anticoagulants ↑ bleeding risk; NSAIDs + ACE inhibitors/diuretics can impair renal function; NSAIDs + methotrexate ↑ methotrexate toxicity; NSAIDs + SSRIs ↑ GI bleed risk. |
| Special populations | Use with caution in pregnancy (especially third trimester) and lactation; monitor renal function in the elderly or those with CKD. |
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Quick FAQ
- What’s the difference between diclofenac and diclofenac sodium?
Diclofenac sodium is simply the sodium salt of diclofenac, used because it dissolves better in water. The active ingredient (diclofenac) is the same; the EC number applies to the drug regardless of salt form.
- Why is the EC number important?
It’s the identifier for the drug’s registration in the European Union. Regulatory dossiers, labeling, and pharmacovigilance reports reference this number.
- Where can I find the EC number for other drugs?
The EMA’s drug database or the European Commission’s “List of approved drugs” will list the EC number next to the generic name.
Feel free to let me know if you need dosing details for a specific formulation or more information on safety monitoring!