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Common side effects of Zejula: Zejula (niraparib) is a medication used to treat ovarian, fallopian tube, or primary peritoneal cancer in women with BRCA1 or BRCA2 mutations. Like all medications, Zejula can cause side effects, some of which are common and may require medical attention. According to the FDA, the most common side effects of Zejula include [1]: * Fatigue (56% of patients) * Nausea (47% of patients) * Vomiting (33% of patients) * Constipation (34% of patients) * Diarrhea (24% of patients) * Abdominal pain (21% of patients) * Dizziness (20% of patients) * Weight loss (18% of patients) * Decreased appetite (16% of patients) Less common but serious side effects: While rare, some patients may experience more severe side effects, including [2]: * Blood disorders (anemia, thrombocytopenia, neutropenia) * Increased risk of bleeding * Low blood pressure * High blood pressure * Dehydration * Kidney injury * Liver damage Additional patient concerns: It's essential for patients taking Zejula to be aware of the following potential risks and side effects: * Ovarian hyperstimulation syndrome (OHSS): Zejula may increase the risk of OHSS, a potentially life-threatening condition that occurs when the ovaries produce too many eggs. * Reproductive effects: Women taking Zejula may experience reduced fertility, and it's essential to discuss fertility options with a doctor before starting treatment. * Bone marrow suppression: Zejula can affect bone marrow, leading to decreased platelet count, white blood cell count, or red blood cell count. Managing side effects: Doctors may adjust the dosage or recommend additional medications to minimize side effects. Patients taking Zejula should follow their doctor's instructions and report any unusual symptoms or side effects promptly. Sources: [1] FDA - Zejula (niraparib) https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209115s000lbl.pdf [2] Prescribing Information - Zejula (niraparib) https://www.drugs.com/pro/zejula.html [3] Patient Information: Zejula (niraparib) Capsules, for Oral Use 1
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