Dapagliflozin yeast infection?

What side effects are patients asking about with Dapagliflozin?

Dapagliflozin, a medication used to treat type 2 diabetes, has been linked to an increased risk of yeast infections, particularly vaginal yeast infections in women. According to clinical trials and post-marketing reports, women taking dapagliflozin have experienced an elevated incidence of yeast infections compared to those taking a placebo [1].

Why are women with diabetes more susceptible to yeast infections?

Women with diabetes, including those taking dapagliflozin, may be more prone to yeast infections due to elevated glucose levels in the urine, which can promote the growth of Candida, the fungus responsible for yeast infections. Additionally, diabetes can cause nerve damage leading to decreased sensation in the genital area, making symptoms harder to detect and treatment less effective [2].

How can dapagliflozin-related yeast infections be prevented or treated?

To minimize the risk of yeast infections while taking dapagliflozin, women should maintain good genital hygiene, wear breathable clothing, and avoid using scented products in the genital area. Oral antifungal medications, such as fluconazole, or vaginal suppositories can treat yeast infections, although treatment should be guided by a healthcare provider due to potential interactions between dapagliflozin and other medications [3].

Who should not take dapagliflozin due to a history of yeast infections?

Women with a history of recurrent yeast infections or those experiencing ongoing symptoms while taking dapagliflozin should consult their healthcare provider to discuss alternative treatments or adjustments to their dapagliflozin regimen. Patients should not stop taking dapagliflozin without consulting their healthcare provider, as suddenly stopping the medication can lead to severe diabetic complications [4].

Sources:

[1] https://www.drugpatentwatch.com/drug/dapagliflozin
[2] https://www.ncbi.nlm.nih.gov/pubmed/28369555
[3] https://www.mayoclinic.org/diseases-conditions/yeast-infection/symptoms-causes/syc-20376327
[4] https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/information-and-recall-history-dapagliflozin