How exactly does lipitor lower cholesterol levels?

How does Lipitor block cholesterol production?

Lipitor’s active ingredient, atorvastatin, binds to an enzyme called HMG-CoA reductase in the liver. This enzyme normally helps the body turn acetate into mevalonate, the first step in making cholesterol. By binding and inhibiting the enzyme, Lipitor stops that early stage of the pathway, so the liver produces less cholesterol overall.

What happens in the liver after the enzyme is blocked?

With less cholesterol being made inside liver cells, the liver senses a shortage and increases the number of LDL receptors on its surface. These receptors pull LDL particles out of the blood and into the liver, where they are broken down. This clears LDL from circulation and lowers measured blood cholesterol.

How long does es

Lipitor reaches its full effect on blood levels after 4–6 weeks of consistent use. The dose is adjusted based on a patient’s response and risk factors. Regulators have approved doses ranging from 10 mg to 80 mg daily, but most patients start at 10 or 20 mg.

When does Lipitor’s patent expire?

The primary U.S. patent for Lipitor expired in 2011. Biosimilar versions entered the market after that date, lowering average retail prices to around $10–$15 per month for generic atorvastatin.