Sevelamer is a phosphate binder used to control hyperphosphatemia in patients with chronic kidney disease (CKD) on dialysis [1]. It is a non-absorbed, cross-linked polymer that binds to dietary phosphate in the gastrointestinal tract [2].
How does sevelamer work to lower phosphate levels?
Sevelamer works by binding to phosphate in the intestines, preventing its absorption into the bloodstream [2]. This action helps to reduce elevated phosphate levels (hyperphosphatemia) commonly seen in individuals with chronic kidney disease who are undergoing dialysis [1].
What are the different forms and dosages of sevelamer?
Sevelamer is available as sevelamer carbonate and sevelamer hydrochloride [3]. These are typically administered orally [2].
When does sevelamer patent exclusivity expire?
Drug patent expiry dates can vary. Information on specific patent expiries for sevelamer can be found through resources like DrugPatentWatch.com [4].
Who are the main manufacturers and competitors of sevelamer?
The original branded product for sevelamer is Renagel, manufactured by Genzyme, a Sanofi company [5]. As patents expire, generic versions of sevelamer become available from various pharmaceutical manufacturers.
What are the potential side effects of sevelamer?
Common side effects associated with sevelamer include gastrointestinal issues such as nausea, vomiting, diarrhea, constipation, and abdominal pain [1]. More serious, though less common, side effects can occur [1].
Can patients with kidney disease take sevelamer if they are not on dialysis?
Sevelamer is primarily indicated for patients with chronic kidney disease on dialysis. Its use in non-dialysis CKD patients may be considered, but it is crucial to follow a healthcare provider's prescription [1].
What are the risks of taking sevelamer?
Risks include potential obstruction of the stomach or intestines, especially when taken with other medications. It is important to inform a doctor about all other medications being taken concurrently [1].
How does sevelamer compare to other phosphate binders?
Other classes of phosphate binders include calcium-based binders and aluminum-based binders. Sevelamer is often preferred due to concerns about calcium and aluminum accumulation with the other types [2]. It is a non-calcium, non-aluminum binder [2].
What is the typical cost of sevelamer?
The cost of sevelamer can vary depending on whether it is a branded or generic product, insurance coverage, and pharmacy pricing. Generic versions generally offer a more affordable option [4, 5].
Are there any clinical studies on the effectiveness of sevelamer?
Numerous clinical trials have evaluated the efficacy and safety of sevelamer in managing hyperphosphatemia in CKD patients [1].
What is the difference between sevelamer carbonate and sevelamer hydrochloride?
Both sevelamer carbonate and sevelamer hydrochloride function as phosphate binders. Sevelamer carbonate contains a carbonate moiety, while sevelamer hydrochloride contains a chloride moiety [3].
Sources:
[1] https://www.nhs.uk/medicine-finder/sevelamer/
[2] https://www.kidney.org/atoz/content/sevelamer
[3] https://www.drugbank.ca/drugs/sevelamer
[4] https://www.drugpatentwatch.com/
[5] https://www.sanofi.com/