What is the Opvee dosage (nalmefene) for opioid overdose?
Opvee is nalmefene, a medicine used to reverse opioid overdose. The dosage for Opvee is based on the patient’s age and whether this is the first dose.
For opioid overdose, the typical adult dosing is a single 2.7 mg intranasal spray given as one dose. If the person does not respond as expected, an additional dose may be given after 2 to 5 minutes, continuing until emergency help takes over.
How often can you repeat Opvee dosing?
If there’s no adequate response after the first intranasal dose, Opvee dosing can be repeated every 2 to 5 minutes. The intent is to maintain breathing and responsiveness while you wait for emergency medical care.
Is the Opvee dosage different for children?
Opvee dosing is determined by age/weight group and is not “weight-based” in the same way as some other medicines. Children and adults generally follow the same intranasal dose approach, but the exact number of sprays and repetition timing should follow the product instructions and the local emergency protocol.
What if the patient’s breathing doesn’t improve?
If the patient is not breathing normally or remains unresponsive, continue opioid overdose care steps:
- Call emergency services immediately.
- Give repeat Opvee doses every 2 to 5 minutes if there is no response.
- Provide rescue breathing/CPR if trained and needed.
Can you give Opvee to someone who took opioids but is already awake?
Yes. Opvee is used when opioid overdose is suspected (for example, slow or stopped breathing, or severe sedation/unresponsiveness). Opioids can wear off and effects can return, so clinicians often monitor even after reversal.
Sources
Opvee (nalmefene) dosage details are product-label specific, and I can’t cite the correct dosing instructions without the exact prescribing information you’re using. If you share the strength/packaging you have (or a photo of the label), I can match the exact “dose and repeat” wording.