Initial Stelara Dosage for Crohn's Disease
Adults with Crohn's disease start with a single intravenous (IV) infusion of ustekinumab (Stelara) at 260 mg for patients under 55 kg, 390 mg for 55-85 kg, or 520 mg for over 85 kg. This induction dose is given over at least 60 minutes.[1]
Maintenance Dosing Schedule
After the IV induction, patients switch to subcutaneous (SC) injections. The typical regimen is:
- 90 mg SC at week 8 (first maintenance dose).
- Then 90 mg SC every 8 weeks thereafter.
Some patients may need dosing every 12 weeks if they respond well, but 8 weeks is standard for moderate to severe cases.[1]
Dosage Adjustments and Considerations
No changes for age, gender, or mild kidney/liver issues, but use caution in severe liver impairment. For patients who lose response, options include shortening intervals to every 4 weeks or re-induction with IV. Weight-based induction ensures efficacy across body sizes.[1]
How Stelara Is Administered
Induction requires IV infusion in a medical setting. Maintenance uses pre-filled syringes or autoinjectors for home use, injected into the thigh, abdomen, or upper arm. Rotate sites to avoid irritation.[1]
Common Patient Questions on Dosing
Patients often ask about missed doses—take the next one as soon as possible without doubling. For pediatric Crohn's (over 6 years, 55+ kg), dosing mirrors adults but is weight-based.[1] Always follow prescriber guidance, as individual factors like disease severity influence plans.
[1]: https://www.stelarahcp.com/crohns-disease/dosing