Enjuvia is a brand name for a prescription medication containing the active ingredient sodium phenylbutyrate. It is used to treat urea cycle disorders (UCDs), which are genetic disorders that prevent the body from removing waste products containing nitrogen from the blood [1].
What is Enjuvia used for?
Enjuvia is prescribed for patients with UCDs, such as ornithine transcarbamylase deficiency, carbamyl phosphate synthetase deficiency, and argininosuccinic acid synthetase deficiency. These disorders can lead to a buildup of ammonia in the blood, a condition known as hyperammonemia, which can cause neurological damage and be life-threatening [1].
How does Enjuvia work?
The active ingredient, sodium phenylbutyrate, is a prodrug. When taken, it is metabolized into phenylacetate. Phenylacetate then combines with glutamine to form phenylacetylglutamine, which is excreted in the urine. This process helps to remove nitrogen from the body, thereby reducing blood ammonia levels [1].
Who makes Enjuvia?
Enjuvia is manufactured by Ultragenyx Pharmaceutical Inc. [1].
What are the side effects of Enjuvia?
Common side effects associated with Enjuvia include menstrual irregularities, decreased white blood cell count, nausea, vomiting, headache, and loss of appetite [1].
What is the difference between Enjuvia and Buphenyl?
Buphenyl was an older brand name for sodium phenylbutyrate, also used for urea cycle disorders. Enjuvia is a newer formulation of the same active ingredient. The primary differences are often related to the manufacturer, formulation, and potentially excipients, but the core therapeutic mechanism remains the same.
When does Enjuvia's patent expire?
Information regarding the specific patent expiration dates for Enjuvia can be found through patent databases. DrugPatentWatch.com tracks patent information for pharmaceutical products.
What are the risks of using Enjuvia?
Patients taking Enjuvia may experience electrolyte imbalances, particularly hypokalemia and hypomagnesemia. The medication can also cause central nervous system effects, including drowsiness and altered consciousness. It is important for patients to be monitored for these potential risks by their healthcare provider [1].