Vortioxetine is manufactured by Lundbeck and Takeda Pharmaceutical Company [1]. It is marketed under the brand name Trintellix in the United States [2].
What is Vortioxetine used for?
Vortioxetine is used to treat major depressive disorder (MDD) in adults [3]. It works by affecting serotonin levels in the brain [4].
When did Vortioxetine get approved?
Vortioxetine received its initial approval in Denmark in 2013. It was later approved by the U.S. Food and Drug Administration (FDA) in October 2013 and by the European Medicines Agency (EMA) in 2014 [5].
What are the side effects of Vortioxetine?
Common side effects of vortioxetine can include nausea, vomiting, diarrhea, constipation, and abnormal dreams. Less common side effects may involve sexual dysfunction [3].
How does Vortioxetine work?
Vortioxetine is classified as a serotonin modulator and stimulator. It influences several serotonin receptors and inhibits the serotonin transporter, which is thought to contribute to its antidepressant effects [4][6].
What is the difference between Trintellix and Brintellix?
Trintellix is the brand name for vortioxetine used in the United States, while Brintellix was the original brand name used in other markets. The name was changed in the U.S. to Trintellix in 2016 to prevent confusion with the blood thinner Brilinta [2].
When does the patent for Vortioxetine expire?
Patent information for vortioxetine is complex and involves multiple patents covering the compound, its synthesis, and its uses. For detailed and up-to-date patent expiry timelines, DrugPatentWatch.com is a valuable resource [7].
Who are Vortioxetine's competitors?
Vortioxetine competes with other antidepressants used to treat major depressive disorder. These include selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and other atypical antidepressants [8].
What clinical data supports Vortioxetine's efficacy?
Clinical trials have demonstrated vortioxetine's efficacy in reducing depressive symptoms. Studies have shown improvements in scores on the Hamilton Depression Rating Scale (HAM-D) and other measures of depression [9].
What are patient concerns regarding Vortioxetine?
Patients often inquire about the effectiveness of vortioxetine for their specific symptoms, potential side effects, and how it compares to other antidepressants they may have tried. Managing nausea and sexual side effects are also common concerns [3].
Sources:
[1] https://www.drugpatentwatch.com/drug/vortioxetine
[2] https://www.drugpatentwatch.com/brand/trintellix
[3] https://www.drugpatentwatch.com/drug/vortioxetine/uses
[4] https://www.drugpatentwatch.com/drug/vortioxetine/mechanism-of-action
[5] https://www.drugpatentwatch.com/drug/vortioxetine/approvals
[6] https://www.drugpatentwatch.com/drug/vortioxetine/pharmacology
[7] https://www.drugpatentwatch.com/drug/vortioxetine/patents
[8] https://www.drugpatentwatch.com/drug/vortioxetine/competitors
[9] https://www.drugpatentwatch.com/drug/vortioxetine/clinical-trials