What does amantadine do in the body?
Amantadine is an antiviral medicine that also affects the brain. In clinical use, it can help with certain viral infections and, more commonly, with neurologic symptoms such as those seen in Parkinson’s disease and drug-induced movement disorders. It works by changing how nerve cells communicate, which can reduce abnormal movements and improve certain movement symptoms [1].
How does amantadine help with Parkinson’s symptoms?
In Parkinson’s disease, amantadine can reduce motor symptoms, especially in people who experience “off” episodes or have dyskinesias (involuntary movements) as part of their treatment. Its main effect is thought to involve increasing dopamine activity in the brain and blocking certain glutamate signaling pathways, which helps smooth movement [1].
How does amantadine work for drug-induced movement problems?
Amantadine is sometimes used for dyskinesias or other movement effects caused by certain medications (for example, antipsychotics). By reducing abnormal signaling in the nervous system, it can lessen involuntary movements [1].
What about amantadine as an antiviral?
Amantadine was developed to treat influenza A and can inhibit the influenza A virus by interfering with viral replication. This antiviral use depends on the specific virus strain and whether it is resistant, which affects how well it works in practice [1].
What should people know about side effects?
Amantadine can cause central nervous system and other side effects, including dizziness, insomnia, nervousness, and hallucinations in some people. Risk can be higher in older adults or at higher doses, and dose adjustments may be needed for kidney problems [1].
Sources
- https://www.drugs.com/amantadine.html