Lipitor (atorvastatin) is a medication that is used to lower cholesterol levels in the blood. It belongs to a class of drugs known as statins, which work by inhibiting the production of cholesterol in the liver [1]. According to a study published in the Journal of Clinical Pharmacology, the absorption of atorvastatin is not affected by the intake of fatty foods. However, the maximum concentration of the drug in the blood is delayed by about 1.25 hours when taken with a high-fat meal [3].

Food can have a significant impact on the absorption and effectiveness of medications. Certain foods can interfere with the absorption of drugs, while others can enhance it. In the case of Lipitor, it is generally recommended that the medication be taken with or without food, as the absorption of atorvastatin is not significantly affected by food intake [2]. However, it is important to note that grapefruit and grapefruit juice should be avoided while taking Lipitor, as they can increase the concentration of the drug in the blood and increase the risk of side effects [2].

In conclusion, while fatty foods may delay the maximum concentration of Lipitor in the blood, they do not significantly affect the absorption of the drug. It is generally recommended to take Lipitor with or without food, but grapefruit and grapefruit juice should be avoided. As with any medication, it is important to follow the instructions of your healthcare provider and pharmacist regarding the proper use and administration of Lipitor [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.uspharmacist.com/article/fooddrug-interactions
[3] https://pubmed.ncbi.nlm.nih.gov/20449528/