Based on the information available, the safety of taking methotrexate with vitamins can depend on several factors, including the specific vitamins involved, the dosage, and the individual's health status.

Methotrexate is a medication commonly used to treat conditions like rheumatoid arthritis, psoriasis, and certain types of cancer [1]. It works by inhibiting the growth of certain cells in the body.

Vitamins, on the other hand, are essential nutrients that our bodies need for various functions, including growth, repair, and maintenance [2].

While vitamins are generally safe, they can interact with certain medications, including methotrexate. For instance, folic acid, a type of B vitamin, can interact with methotrexate. Folic acid is often recommended to help reduce some of the side effects of methotrexate, such as mouth sores and stomach upset [3]. However, high doses of folic acid can potentially reduce the effectiveness of methotrexate [3].

Vitamin A and vitamin D can also interact with methotrexate, potentially leading to increased side effects [4].

Therefore, it's crucial to consult with a healthcare provider before starting any new supplements or medications, including vitamins, when taking methotrexate. They can provide guidance based on the individual's specific health situation and the dosages involved.

Sources:
[1] "Methotrexate." Mayo Clinic, Mayo Foundation for Medical Education and Research, 16 Nov. 2021, www.mayoclinic.org/drugs-supplements/methotrexate-oral-route-injection-route/description/drg-20062730.
[2] "Vitamins." MedlinePlus, U.S. National Library of Medicine, 11 Jan. 2022, medlineplus.gov/vitamins.html.
[3] "Folic Acid and Methotrexate." Arthritis Foundation, 2019, www.arthritis.org/health-wellness/treatment/drug-education/rheumatoid-arthritis-drugs/folic-acid-and-methotrexate.
[4] "Methotrexate Interactions." Drugs.com, www.drugs.com/drug-interactions/methotrexate,methotrexate.html.
[5] "Methotrexate." DrugPatentWatch, 2022, www.drugpatentwatch.com/drugs/methotrexate.