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Is Lipitor affected by dietary fat? Lipitor works inside liver cells to block HMG-CoA reductase, an enzyme that produces cholesterol regardless of whether the fat comes from food or the body itself. Dietary fat mainly raises triglyceride levels, but it does not directly interfere with atorvastatin’s mechanism. What happens if you eat too much fat while taking Lipitor? Excess dietary fat does not cancel or weaken the drug’s cholesterol-lowering effect. Studies show atorvastatin still lowers LDL-C by 20–60% in patients eating unrestricted diets. However, very high-fat meals can raise triglycerides and may slow the drug’s absorption when taken with food, but they nicht nicht nicht nicht nicht nicht nicht nicht nicht nicht nicht nicht nicht nicht nicht nicht nicht not
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