Prednisolone API refers to the active pharmaceutical ingredient prednisolone itself—the synthetic glucocorticoid used as the active component in many anti-inflammatory and immunosuppressive medicines.
Key facts about prednisolone API:
- CAS number: 50-24-8
- Molecular formula: C21H28O5
- Molecular weight: ~360.44 g/mol
- Class: synthetic glucocorticoid (anti-inflammatory and immunosuppressive)
- Common uses (as an API): basis for many corticosteroid tablets, suspensions, or injectables used to treat inflammatory, autoimmune, dermatologic, allergic, respiratory, and GI conditions; often substituted by doctors for conditions like asthma, rheumatoid arthritis, ulcerative colitis, and severe allergic reactions
- Prodrug note: prednisone is a prodrug that is converted to prednisolone in the body (prednisolone is the active form)
Basic pharmacology (high level):
- Mechanism: glucocorticoid receptor agonist; suppresses multiple inflammatory pathways
- Bioavailability: typically good when taken orally (varies with formulation)
- Metabolism: primarily hepatic (CYP enzymes)
- Half-life: relatively short in plasma, but biological effects persist longer
Safety considerations (high level):
- Long-term use can cause hyperglycemia, hypertension, osteoporosis, infection risk, mood changes, and HPA axis suppression
- Caution in active infections, peptic ulcers, diabetes, glaucoma, pregnancy/lactation (benefits and risks must be weighed)
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