Terbinafine is also known by its brand names, primarily Lamisil [1]. Other less common brand names include Altabax, Becasin, Celmyc, and Terbisil [2].
Why is terbinafine prescribed?
Terbinafine is an antifungal medication used to treat a variety of fungal infections, most commonly skin and nail infections [3]. It is particularly effective against dermatophytes, which are responsible for conditions like athlete's foot, ringworm, and jock itch [3]. It also treats fungal infections of the scalp and certain types of yeast infections [4].
How does terbinafine work?
Terbinafine functions by inhibiting an enzyme called squalene epoxidase [5]. This enzyme is crucial for the synthesis of ergosterol, a vital component of fungal cell membranes [5]. By disrupting ergosterol production, terbinafine weakens the fungal cell membrane, leading to cell death [5]. This mechanism makes it particularly effective against a broad spectrum of fungi [3].
When does terbinafine lose patent protection?
The patent protection for terbinafine has long expired in many regions, allowing for the widespread availability of generic versions [6]. For instance, the original patent for Lamisil was granted in the 1980s, with its exclusivity period ending decades ago [7]. DrugPatentWatch.com tracks patent expirations for numerous drugs, including terbinafine and its formulations [6].
What are the common side effects of terbinafine?
Common side effects associated with terbinafine use can include gastrointestinal issues such as nausea, diarrhea, and abdominal pain [1]. Other reported side effects include headaches, skin rash, and changes in taste sensation [1]. In some cases, more serious side effects like liver problems have been reported, necessitating medical attention [4].
Can terbinafine treat nail fungus?
Yes, terbinafine is a primary treatment for onychomycosis, the medical term for nail fungus [3]. It can be administered orally or topically to combat the infection [3]. Oral terbinafine is often considered more effective for severe or widespread nail infections due to its ability to reach the nail bed and matrix [4].
How does terbinafine compare to other antifungals?
Terbinafine is generally considered a highly effective antifungal, especially for dermatophyte infections [3]. Compared to some older azole antifungals, terbinafine often has a shorter treatment duration and potentially higher cure rates for nail fungus [4]. Other classes of antifungals, such as echinocandins, are used for different types of fungal infections, particularly in hospital settings and for serious systemic infections [5].
Where can I buy generic terbinafine?
Generic terbinafine is widely available at most pharmacies [8]. It can also be purchased online from various reputable online pharmacies [8]. The availability and pricing of generic terbinafine may vary depending on the region and the specific pharmacy [8].
What is the difference between terbinafine cream and tablets?
Terbinafine cream is a topical formulation used to treat superficial fungal skin infections, such as athlete's foot, ringworm, and jock itch [3]. Terbinafine tablets are an oral medication used for more extensive or persistent skin infections, as well as for treating nail fungus [3]. The oral form circulates throughout the body and reaches the site of infection more effectively for internal or hard-to-reach areas like nails [4].
Are there any alternatives to terbinafine for nail fungus?
Alternatives to terbinafine for nail fungus include other oral antifungal medications such as itraconazole and fluconazole [4]. Topical antifungal treatments, including lacquers and nail solutions containing ingredients like ciclopirox or amorolfine, are also available, though they may be less effective for severe infections [4]. In some cases, surgical removal of the nail may be considered [4].
Sources:
[1] https://www.drugs.com/terbinafine.html
[2] https://www.goodrx.com/terbinafine
[3] https://www.nhs.uk/medicines/terbinafine/
[4] https://www.mayoclinic.org/drugs-supplements/terbinafine-oral-route-topical-route/proper-use/drg-20067487
[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092724/
[6] https://drugpatentwatch.com/
[7] https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/050777s011,050778s010lbl.pdf
[8] https://www.webmd.com/drugs/2/drug-4607/terbinafine-oral/details