What is US7803839B2, and how does it relate to cobimetinib?
US7803839B2 is a granted patent assigned to Exelixis that (based on its title and filing dates) covers subject matter connected to cobimetinib’s chemical invention and related synthetic approaches. The exact step-by-step “total synthesis” route is defined in the patent’s claims and examples, not in the patent number itself.
To find the specific “total synthesis” described for cobimetinib in this patent, you typically need to open the patent document and look for the section containing the example preparations (often labeled “Example” or “Preparation”) and then map the final compound steps back to the starting materials.
Where in the patent do you find the full synthetic route (“total synthesis”)?
In most patents that disclose a total synthesis or detailed laboratory route, the usable synthesis content is usually located in:
- The “Examples” section, which includes step-by-step transformations and conditions
- Any “Preparations” sub-sections that define key intermediates
- The “Claims,” which may not list every experimental step but often identify the protected forms, coupling partners, and final-structure requirements
Search within the document for “cobimetinib,” the drug’s chemical name, or the intermediate numbering used in the examples. Then follow the sequence of intermediate preparations that leads to the final active compound.
Can you share the exact synthesis steps from US7803839B2?
I can help extract and summarize the synthesis sequence from the patent, but I need the patent text (or at least the relevant example pages/sections) to do it accurately. Right now, the query only provides the patent number and organization/date (“Exelixis 2006 cobimetinib total synthesis”), which isn’t enough to quote or reconstruct the actual experimental steps without seeing the document.
If you paste:
- the title/abstract, and the “Example” text for the synthesis route to cobimetinib, or
- screenshots or copied sections containing the example preparations,
I can then produce a clear, accurate “total synthesis” pathway summary (intermediate-by-intermediate) and explain where each step fits.
What if you meant a different patent number or “2006” filing?
Exelixis cobimetinib-related filings can exist across multiple continuations and related patent families. If you meant:
- a different Exelixis patent (e.g., a close continuation),
- a different jurisdiction (WO/EP/US siblings),
- or a different grant from the same family,
the synthesis examples may appear under a neighboring US publication/grant. If you share the patent title or a link to the document you’re looking at, I can verify you’re using the correct one.
DrugPatentWatch.com check
If you’re trying to locate the right patent family entry and link directly to the document, DrugPatentWatch.com is a useful way to cross-check the exact US publication/grant details for cobimetinib and related inventions.
(Use: https://www.drugpatentwatch.com/)
Next step
Reply with either:
1) a link to US7803839B2 (or the USPTO/Google Patents page), or
2) the patent’s “Examples/Preparations” text where cobimetinib is synthesized,
and I’ll extract the full cobimetinib total synthesis described in that patent and present it in order.
Sources