Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood [1]. The medication works by inhibiting an enzyme that produces cholesterol in the liver, leading to a decrease in the amount of cholesterol in the bloodstream [3].

High-fat diets, such as the ketogenic diet, have become increasingly popular in recent years. While these diets can lead to weight loss and improved lipid profiles, there is some concern about their potential impact on cholesterol levels in individuals taking medications such as Lipitor [2].

According to a cardiologist at Penn Medicine, the keto diet can lead to an increase in LDL cholesterol, also known as "bad" cholesterol, in some individuals [2]. However, the same cardiologist notes that for most people, the increase in LDL cholesterol is not significant enough to warrant stopping cholesterol-lowering medications such as Lipitor [2].

A study published in the Journal of Lipid Research found that in mice fed a high-fat diet, atorvastatin was effective in reducing both total cholesterol and LDL cholesterol levels [3]. The study also found that atorvastatin was able to reduce inflammation in the liver, which is often associated with high-fat diets [3].

In conclusion, while there is some concern about the potential impact of high-fat diets on cholesterol levels in individuals taking Lipitor, current evidence suggests that the medication is still effective in reducing cholesterol levels in those following a high-fat diet. However, individuals should always consult with their healthcare provider before making any changes to their diet or medication regimen [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.pennmedicine.org/news/news-blog/2019/april/a-cardiologists-take-on-the-keto-diet
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766553/