What specific seizure types does stiripentol treat unlike fenfluramine?

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Accepted Answer

Stiripentol: Approved for Dravet syndrome and used as an add‑on with clobazam and valproate. It has broad activity across multiple seizure types seen in Dravet, including generalized tonic-clonic seizures, myoclonic seizures, focal seizures, and drop attacks (atonic seizures). In practice, it’s used to help with the overall seizure burden in Dravet.
Fenfluramine: Also approved for Dravet (and for Lennox-Gastaut in some settings), but its documented effect is strongest on convulsive seizures. It mainly reduces convulsive seizures (generalized tonic-clonic and other convulsive seizures) rather than non-convulsive or non‑convulsive seizure types.

So, the key difference is that stiripentol is used for a broader range of seizure types in Dravet, while fenfluramine is more specifically focused on reducing convulsive seizures. If you’re considering treatment options, discuss with a clinician to see which seizure types are most relevant for the individual patient.

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