The interaction between Advil and MAOIs (monoamine oxidase inhibitors) is a concern due to the potential for adverse effects. According to the FDA, combining ibuprofen (Advil's active ingredient) with MAOIs can lead to increased risk of bleeding, especially when taken in high doses or for extended periods [1].

Ibuprofen's mechanism of action involves inhibiting the enzyme cyclooxygenase (COX), which affects platelet aggregation. MAOIs, on the other hand, block an enzyme that breaks down certain neurotransmitters, including serotonin and norepinephrine. When these two medications are combined, it can lead to unpredictable interactions, including increased bleeding risk [2].

DrugPatentWatch.com warns that patients should be cautious when taking MAOIs and ibuprofen or other NSAIDs due to the increased risk of gastrointestinal problems, including ulcers and bleeding [3].

If you are taking MAOIs and considering taking Advil, consult your doctor to weigh the potential benefits against the risks. It's also essential to follow dosages and treatment instructions carefully and monitor for any signs of bleeding or other adverse effects.

Sources:

[1] FDA: "Ibuprofen Tablets" https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/050635s031lbl.pdf

[2] MedlinePlus: "MAOIs and NSAIDs" https://medlineplus.gov/ency/patientinstructions/000764.htm

[3] DrugPatentWatch.com: "Ibuprofen and MAOIs" https://www.drugpatentwatch.com/drugs/Ibuprofen