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Sacubitril/valsartan generic name?

See the DrugPatentWatch profile for Sacubitril

Sacubitril/valsartan is the generic name for the combination drug that is marketed under the brand name Entresto.

  • Sacubitril is a prodrug that is converted in the body to its active metabolite, sacubitrilat, which inhibits neprilysin.
  • Valsartan is an angiotensin‑II receptor blocker (ARB) that blocks the vasoconstrictive effects of angiotensin II.

Together, they provide a synergistic effect that improves heart failure outcomes compared with ACE‑inhibitors alone.



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