What neurological side effects can Lariam (mefloquine) cause?
Lariam (mefloquine) can cause nervous-system (neurological/psychiatric) side effects. Reported reactions include symptoms affecting mood, thinking, and sleep, such as confusion and anxiety, and more severe effects in some cases.
What mental health and brain-related symptoms should patients watch for?
People taking Lariam have reported neurological or neuropsychiatric effects such as:
- Confusion or disorientation
- Anxiety, agitation, or restlessness
- Hallucinations (seeing or hearing things that aren’t there)
- Depression
- Suicidal thoughts (or worsening of suicidal ideation)
Can Lariam cause seizures or other serious neurologic problems?
Yes. Lariam has warnings for serious neurologic effects. In particular, it can be associated with seizures and other severe reactions, and these risks are part of why the drug is used with caution in patients with a history of certain psychiatric or neurologic conditions.
Who is more at risk for neurological side effects?
Risk is higher in people with:
- Past psychiatric illness (especially conditions such as depression or anxiety disorders)
- Prior neurologic problems or seizures
- Prior sensitivity to mefloquine or similar medicines
Clinicians typically screen for these histories before prescribing Lariam.
When should someone stop Lariam and seek urgent care?
Seek urgent medical care if neurological symptoms become severe or include signs such as:
- Confusion that is worsening
- Hallucinations
- New or worsening depression
- Any suicidal thoughts
- Seizure or fainting with convulsions
Are there alternatives if neurological side effects are a concern?
If neurological side effects are a concern, prescribers often consider other malaria-prevention options (depending on where you’re traveling, resistance patterns, and your medical history).
If you share your destination and whether you’re using Lariam for prevention or treatment, I can help narrow down common alternatives used for that scenario.