If you’re trying to find patents on histamine biosynthetic production using Google Patents, here’s a quick guide and what to expect.
How to search (step-by-step)
- Go to patents.google.com.
- Try these core queries (you can mix with OR/AND):
- "histamine biosynthesis"
- "histamine production"
- "histidine decarboxylase" (the enzyme that makes histamine)
- "biotechnological production of histamine"
- "fermentation histamine production" or "bioprocess histamine"
- Use quotes for exact phrases to reduce noise.
- Refine results:
- Filter to Patents (not non-patent literature).
Filter by status: Active, Granted, Published, or a specific date range.
Sort by: Newest or Relevance.
- Use advanced search for field-specific results:
- Example: title:(histamine) AND abstract:(biosynthesis OR production)
- Or: claims:(histamine OR histidine decarboxylase)
- Broaden with synonyms:
- histamine biosynthesis, histamine synthesis, histidine decarboxylase, HDC, histamine production in fermentation, bioproduction of histamine.
What you’ll likely see
- Topics in play:
- Engineering microbes (bacteria or yeast) to overproduce histamine via histidine decarboxylase (HDC) pathways.
- Host organisms, expression systems, promoters, and enzyme variants used to boost histamine yields.
- Downstream processing and purification of histamine or methods to minimize histamine formation in foods (the latter is common in food-safety patents and may appear in the same search space).
- Patents on optimizing co-factors (e.g., PLP) or transporters to export histamine from cells.
- Typical claim themes:
- A host microorganism engineered to produce histamine from histidine.
- A method of producing histamine in a fermentation or biocatalytic process.
- Processes for purification, stabilization, or selective recovery of histamine.
- Important caveats:
- Some patents will focus on preventing histamine formation in foods rather than producing it industrially.
- Not all results will be directly about scalable production; some may be about diagnostic, analytical, or regulatory aspects related to histamine.
If you want, I can help you interpret results you find:
- Paste in or summarize any patent titles/claims you’re looking at, and I’ll help explain the scope, the claimed methods, and potential relevance.
- I can also help you build a broader set of search strings to cover more ground (e.g., adding “bioprocessing,” “production in microorganism,” “glycine decarboxylase” variants if relevant, etc.).
Would you like me to draft a longer list of search strings to run, or do you have specific patent results you want help analyzing?