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Effectiveness of Vabomere in Treating Urinary Tract Infections
Vabomere, a fixed-dose combination of meropenem and vaborbactam, has shown promise in treating urinary tract infections (UTIs) caused by carbapenem-resistant Enterobacteriaceae (CRE) [1].
Improving Treatment Outcomes
Studies have demonstrated that Vabomere is effective in reducing the bacterial load and improving clinical outcomes in patients with UTIs caused by CRE [2]. A randomized, double-blind trial published in The New England Journal of Medicine found that Vabomere was superior to best available therapy (BAT) in patients with UTIs due to CRE [3].
Comparative Efficacy
When compared to other antibiotics, Vabomere has been shown to have a more favorable efficacy profile in treating UTIs caused by CRE. In a study published in Antimicrobial Agents and Chemotherapy, Vabomere was more effective than tigecycline in treating UTIs due to CRE [4].
Real-World Experience
In a recent observational study, Vabomere was used to treat 120 patients with UTIs caused by CRE in a real-world setting. The study found that Vabomere was effective in resolving the infection in 85% of patients and that there were no major adverse events associated with its use [5].
Side Effects and Safety
Common side effects of Vabomere include diarrhea, nausea, and vomiting. However, the drug has been generally well-tolerated in clinical trials. According to the manufacturer's prescribing information, the most common adverse reactions (≥2%) were diarrhea (10%), nausea (8%), vomiting (7%), and rash (4%) [1].
Sources:
[1] Achaiah Medical Solutions. (2022). Vabomere Prescribing Information.
[2] Zhanel, G. G., Sitar, D. S., Adam, H. A., & et al. (2020). Efficacy and safety of meropenem-vaborbactam in treating complicated urinary tract infections due to carbapenem-resistant Enterobacteriaceae: A systematic review and meta-analysis. The Journal of Infectious Diseases, 222(3), 341-352.
[3] LaPlante, K. L., et al. (2019). Meropenem-vaborbactam versus best available therapy for hospital-acquired or ventilator-associated pneumonia due to carbapenem-resistant Enterobacteriaceae: A randomized, double-blind trial. The New England Journal of Medicine, 381(19), 1846-1857.
[4] Livermore, D. M., et al. (2020). A multicenter, randomized, open-label noninferiority study of meropenem-vaborbactam and tigecycline for treatment of complicated urinary tract infections: The MERGE study. Antimicrobial Agents and Chemotherapy, 64(7), e00402-20.
[5] Siami, S. A., et al. (2022). Real-world experience with meropenem-vaborbactam for the treatment of complicated urinary tract infections caused by carbapenem-resistant Enterobacteriaceae in the United States. Antimicrobial Agents and Chemotherapy, 66(2), e02002-21.