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Does advil dosage need adjusting with antidepressants?

Based on the information provided, there is no explicit statement about the need to adjust Advil (ibuprofen) dosage when taking antidepressants. However, it is well-known that both Advil and antidepressants can have effects on the gastrointestinal system, increasing the risk of stomach ulcers and bleeding [1, 2]. Therefore, it is crucial to monitor patients closely when they are taking both Advil and antidepressants.

Additionally, it is important to note that certain antidepressants, such as amitriptyline, can cause drowsiness and dizziness, and taking Advil may exacerbate these side effects [2]. Patients should be advised to avoid operating heavy machinery or driving when taking both medications.

In general, healthcare providers should always consider a patient's complete medication regimen when prescribing new medications or adjusting dosages. Patients should inform their healthcare providers of all medications they are taking, including over-the-counter drugs like Advil, to ensure safe and effective treatment [3].

In summary, while there is no specific information stating that Advil dosage needs adjusting with antidepressants, it is crucial to monitor patients closely when they are taking both medications due to potential gastrointestinal and central nervous system side effects.


[1] DrugPatentWatch. (n.d.). Advil (Ibuprofen) - Patent Information and History. Retrieved from <>

[2] NHS. (2021, February 22). Amitriptyline for depression. Retrieved from <>

[3] UCSF Memory and Aging Center. (n.d.). Medications for Dementia. Retrieved from <>

Follow-up:   Does antidepressant use affect Advil's recommended dosage? Should Advil dosage be adjusted when taking antidepressants? How does antidepressant interaction affect Advil's safe usage?

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