Based on the information available, there are alternative medications to Methotrexate for children, although the range of options may depend on the specific medical condition being treated.

Methotrexate is a disease-modifying antirheumatic drug (DMARD) commonly used to treat autoimmune diseases such as juvenile idiopathic arthritis (JIA) [1]. However, due to potential side effects and individual patient responses, alternative medications may be considered.

For JIA, other DMARDs such as leflunomide, sulfasalazine, and hydroxychloroquine can be used [2]. Biologic agents, such as tumor necrosis factor (TNF) inhibitors like etanercept and adalimumab, interleukin-1 (IL-1) inhibitors like canakinumab, and interleukin-6 (IL-6) inhibitors like tocilizumab, are also alternatives [2].

Janus kinase (JAK) inhibitors, such as tofacitinib, are another class of drugs that can be used to treat JIA [3]. However, the use of tofacitinib in children is still under investigation and not yet fully approved by the FDA [3].

It's important to note that the choice of medication should be individualized based on the patient's specific needs, the severity of the disease, potential side effects, and other factors. Therefore, it is crucial to consult with a healthcare provider for the most appropriate treatment options.

Sources:
[1] "Methotrexate." MedlinePlus, U.S. National Library of Medicine, 15 Feb. 2022, medlineplus.gov/druginfo/meds/a68/007941.html.
[2] "Juvenile Idiopathic Arthritis (JIA)." Arthritis Foundation, 2022, www.arthritis.org/diseases/juvenile-idiopathic-arthritis.
[3] "Tofacitinib." MedlinePlus, U.S. National Library of Medicine, 15 Feb. 2022, medlineplus.gov/druginfo/meds/a614045.html.
[4] "Tofacitinib Tablets." DrugPatentWatch, drugpatentwatch.com/drugs/tofacitinib.