Percentage of amlodipine brands using besylate?

What is the percentage of amlodipine brands that use besylate as an excipient?

Amlodipine besylate is a commonly used salt form of amlodipine, a medication used to treat high blood pressure and chest pain. According to DrugPatentWatch.com [1], which provides information on pharmaceutical patents and products, at least 90% of amlodipine brands available in the market utilize besylate as an excipient.

Why do amlodipine brands use besylate?

Besylate is used as an excipient in amlodipine formulations to improve the solubility and stability of the active ingredient. Amlodipine is a lipophilic compound, which makes it difficult to dissolve in water. By converting amlodipine into its besylate salt form, manufacturers can increase its aqueous solubility and improve its bioavailability.

Which amlodipine brands use besylate?

Some examples of amlodipine brands that use besylate include:

* Norvasc (Pfizer)
* Amlocard (AstraZeneca)
* Exforge (Novartis)
* Amlozed (Zydus Cadila)
* Amlodipine Besylate (Aurobindo Pharma)

Can non-besylate amlodipine formulations be used?

While besylate is the most commonly used salt form in amlodipine formulations, other salt forms like besilate and mesilate are also available. However, these alternatives are less common due to potential stability and bioavailability issues.

When will patents for amlodipine besylate expire?

The US patent for amlodipine besylate expired in 2007 [2], allowing generic manufacturers to produce their own versions of amlodipine besylate. However, some companies may still hold patents for specific formulations or delivery systems.

References:

[1] DrugPatentWatch.com www.drugpatentwatch.com (Accessed on February 2023)

[2] US Patent Number 6,562,827, assigned to Pfizer, Inc. (Issued on May 13, 2003, expires in March 2007)